Integrating genetic, neuroimaging and outcomes data to identify novel therapeutic targets and precision medicine strategies for patients with stroke and aging-related conditions.

Our research lies at the interphase of clinical neurology, neuroimaging, population genetics and genomic medicine. We are interested in understanding how common and rare genetic variation influences the occurrence, severity, functional outcome, and recurrence of stroke. We are also interested in understanding how genetic variation related to cardiovascular disease influences Aging-related traits and conditions, including disability, cognitive decline and dementia. We use genetic variation to: (1) identify novel biological mechanisms and therapeutic targets for our diseases of interest; (2) answer non-genetic epidemiological questions, utilizing genetic variants as instruments; and (3) develop precision medicine tools aimed at risk-stratifying persons according to their genetic profile.